vidarabine

Vidarabine other names for Vidarabine: Adenosine, trade name for Vidarabine: Adenosine. Properties: white crystalline powder, slightly soluble in water, phosphate soluble in water. It is effective against herpes simplex virus HSV1 and HSV2 in the treatment of herpes simplex virus encephalitis and in the treatment of herpes zoster and chickenpox infections in immunosuppressed patients. But not against cytomegalovirus. The monophosphate ester of this product has the effect of inhibiting the replication of hepatitis B virus.

The enzymatic synthesis of adenosine can be applied to large-scale industrial production.

Adenosine is an important antiviral drug, which is mainly used in the treatment of chronic hepatitis B, herpes zoster encephalitis and herpetic keratitis. It is also an important intermediate of adenosine monophosphate. At present, there are no domestic factories engaged in synthetic production.

The synthesis of nucleoside by nucleoside phosphorylase is one of the difficulties and hotspots in nucleic acid pharmaceutical chemistry. The new nucleoside can be obtained by using this enzyme to catalyze the transfer reaction of glycoside. However, the chemical synthesis of glycoside is very easy, so it can be catalyzed by glycoside to get adenosine.

Cytarabine mainly acts on pyrimidine antimetabolites during cell S proliferation, and interferes cell proliferation by inhibiting the synthesis of cell DNA.

Cytarabine can treat the following malignancies

Acute non-lymphoblastic leukemia

Acute lymphoblastic leukemia

Chronic myeloid leukemia

Cytarabine can be administered intravenously or subcutaneously.